This course focuses on a variety of attacks on computer systems. Some of them are classical attacks, and some are quite new, such as the recently discovered Dirty COW, Meltdown, and Spectre attacks. The course emphasizes hands-on learning. For each attack covered, students not only learn how the attack work in theory, they also learn how to actually conduct the attack, in a contained virtual machine environment. The hands-on exercises developed by the instructor are called SEEDlabs, and they are being used by over 1000 institutes worldwide. The course is based on the textbook written by the instructor. The book, titled "Computer &Internet Security:A Hands-on Approach, 2nd Edition", has been adopted by over 120 universities and colleges worldwide.