Glucose-6-phosphate dehydrogenase (G6PD) deficiency is definitely a mouthful. It is a rare, hereditary health condition that causes red blood cells to break down faster than they should when the body is exposed to certain foods, drugs, or infections. This condition is called hemolysis and it is a direct result of low levels of the G6PD enzyme or if the patient is missing the enzyme altogether. summary and recommendations: disease definition and epidemiology of Glucose 6 phosphate dehydrogenase deficiency, genetics, clinical features, differential diagnosis, when to suspect Glucose 6 phosphate dehydrogenase deficiency, evaluation, and management. Definition, Role of Glucose 6 phosphate dehydrogenase enzyme, Causes, Signs and symptoms, Classifications, Factors triggering this deficiency, Diagnosis, Treatment.Medicines and other substances likely to be unsafe in moderate to severe Glucose 6 phosphate dehydrogenase deficiency .chemical exposures and foods.Medicines that are probably safe given in therapeutical doses in Glucose 6 phosphate dehydrogenase deficiency. summary and recommendations: disease definition and epidemiology of Glucose 6 phosphate dehydrogenase deficiency, genetics, clinical features, differential diagnosis, when to suspect Glucose 6 phosphate dehydrogenase deficiency, evaluation, and management .G6PD is an inherited X-linked recessive condition caused by gene mutations. This makes it more likely for males to develop it because they only have one X chromosome. Females are generally carriers, but it often does not produce symptoms because they have two X chromosomes. So if a female patient has the mutation on one X chromosome, they still have another chromosome without a mutation.